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Off-site Fibrosis Links, User Submitted

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Thu Sep 4

• Coupling of Cardiac Electrical Activity Over Extended Distances by Fibroblasts of Cardiac Origin -- Gaudesius et al. 93 (5): 421 -- Circulation Research: Involvement of mechanical stretch in this phenomenon was excluded by showing that inserts consisting of communication- deficient HeLa cells were incapable of supporting propagation. In contrast, HeLa cells expressing connexin43 permitted impulse conduction over distances as long as 600 µm. Immunocytochem istry showed that fibroblasts and cardiomyocytes expressed connexin43 and connexin45, whereas connexin40 was absent. These results illustrate that fibroblasts of cardiac origin are capable of synchronizing electrical activity of multicellular cardiac tissue over extended distances through electrotonic interactions. This synchronizatio n is accompanied by extremely large local conduction delays, which might contribute to the generation of arrhythmias in fibrotic hearts.
• Electrotonic Modulation of Cardiac Impulse Conduction by Myofibroblasts -- Miragoli et al. 98 (6): 801 -- Circulation Research: Myofibroblasts affected {theta} and dV/dtmax in a cell density-depend ent manner; a gradual increase of myofibroblast- to-cardiomyocy te ratios up to 7:100 caused an increase of both {theta} and dV/dtmax, which was followed by a progressive decline at higher ratios. On full coverage of the strands with myofibroblasts (ratio >20:100), {theta} fell <200 mm/s. This biphasic dependence of {theta} and dV/dtmax on myofibroblast density is reminiscent of "supernor mal conduction&quo t; and is explained by a myofibroblast density-depend ent gradual depolarization of the cardiomyocyte strands from ?78 mV to ?50 mV as measured using microelectrode recordings. These findings suggest that myofibroblasts , apart from their role in structural remodeling, might contribute to arrhythmogenes is by direct electrotonic modulation of conduction and that prevention of their appearance might represent an antiarrhythmic therapeutic target.
• GENIALITY Diagnóstico Genético Preimplantacio nal: centro biotecnológico de I+D+i en el campo de la genética reproductiva

Wed Sep 3

• American Thoracic Society: the American Thoracic Society
• ECFS Conference Website: European Cystic Fibrosis Society (ECFS) CONFERENCES
• Premi Josep Parera

Mon Sep 1

• YouTube - I Congreso de Fibrosis Quistica

Fri Aug 22

• Otorgan doctorado honoris causa a Céline Dion en Canadá - El Universal - Espectáculos

Wed Aug 20

• Endogenous relaxin is a naturally occurring modula...[Endo crinology. 2007] - PubMed Result: "Kelly DJ"[Autho r]
• Relaxin ameliorates fibrosis in experimental diabe...[Endoc rinology. 2008] - PubMed Result: "Kelly DJ"[Autho r]

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Off-site Fibrosis Research Links

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